Professor Khan is the Director of Rehabilitation Services and Clinical Director, Australian Rehabilitation Research Centre (RMH); at the Royal Melbourne Hospital (RMH), Melbourne Health. She is also Clinical Professor, Department of Medicine, the University of Melbourne; Adjunct Professor, Disability Inclusive Unit, Nossal Institute of Global Health and School of Public Health and Preventative Medicine, Monash University. She is the Chair-Elect, of the International Society of Physical and Rehabilitation Medicine (ISPRM) - Disaster Rehabilitation Committee (DRC) and Executive member of the International Disaster Committee WHO- LC ISPRM. She is Honorary Fellow of the National Aging and Research Institute and the Melbourne EpiCentre, Melbourne Health. She represents 9 public hospital networks in Victoria at the Clinical Leadership Group for the Care of the Older People, Department of Health Victoria, Australia (Disability policy and planning).

She currently holds number of executive positions, including: Representative for the Western Pacific Region WHO, ICF Research Branch, Ludwig-Maximilian University; Executive member & Co-ordinating Editor, the Cochrane Multiple Sclerosis Review group, Milan; Executive member (Regional representative for Asia, Australia and Oceania), International Society of Physical Medicine and Rehabilitation; Vice-Chair, Research Committee for the International Society of Physical and Rehabilitation Medicine; Australian representative for Steering group for the Psychosocial Influences upon Chronic Disease Outcomes across Europe (PICDOE), University of Leeds UK.

She currently holds a number of international academic research appointments, which include; Senior Research Fellow at: Department of Rehabilitation and Palliative Care; Institute of Neurology, Department of Brain Repair & Rehabilitation, Kings College London; Department of Neuroimmunology and Rehabilitation, University of Hamburg; Department of Neurorehabilitation, Valens Klinik Switzerland; Oxford Centre of Enablement UK; Leeds University UK; and Karolinska University Sweden.

She has a leadership role in rehabilitative care in Australia and extensive experience in evidence based health outcomes research, particulary neurological conditions such as Multiple sclerosis, Guillain Barre Syndrome, stroke, brain tumours, Motor Neuron Disease, Spina bifida, etc. and health services research. She has received numerous awards in recognition for her work in promoting evidence-based practices in NeuroRehabilitation. She is also currently involved in disaster relief and capacity building initiatives, and leads ‘RMH Rehabilitation Emergency Medical Team’ and ‘RMH Flying Faculty’, She has published over 300 scientific papers in academic journals (including 18 Cochrane reviews, 20 book chapters), and is invited speaker at national and international conferences (over 60 presentations in last 5 years). She leads a team of interdisciplinary researchers (medical and allied health), implementing and evaluating healthcare innovations and quality improvement programs. She currently supervises 6 PhD and 3 MD students at the University of Melbourne. She is also a reviewer for more than ten neuroscience and rehabilitative care journals.